​Clinical Trials for Cancer | Open Trials

Find a clinical trial that is right for you. Below is a categorized list of all of our studies updated monthly (organized and broken down by type) so you know you're getting the latest information available. All of these trials listed below are currently recruiting. To refer a patient or enroll in a currently recruiting cancer cohort, call a research nurse at the Lindner Research Center at 513-585-0844.

Click on a cancer type below to jump to that section.

Breast cancer - Non-metastatic

Her-2 positive

• A011801: T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial - Full Text View - ClinicalTrials.gov
  

• AstraZeneca Olympian: Study Details | Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer | ClinicalTrials.gov

• Lilly J2J-MC-JZLH: Study Details | A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer | ClinicalTrials.gov

Breast Cancer - Metastatic

ER/PR positive

• SERENA 4-NCT04711252  A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease. - Full Text View - ClinicalTrials.gov
  

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Duality Biologics

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov

Her-2 positive

• SWOG 1501-NCT03418961  S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer - Full Text View - ClinicalTrials.gov

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• ImmuneOnco  IMM2902, a HER2/SIRPα Bispecific mAb-Trap Antibody-receptor Fusion Protein, in Patients With HER2-expressing Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov

• Duality Biologics

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov​
  

• Destiny 7

Triple negative

• Miracogen MRG004A-001 A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Destiny 7  A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Duality Biologics

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov

• Ascendis TCTLR-101: Study Details | A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors | ClinicalTrials.gov

• Volastra Therapeutics VLS-1488-2201: Study Details | A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer | ClinicalTrials.gov

Lung cancer - Non-metastatic

Small cell

• Ascendis ASND0029: Study Details | A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or Chemotherapy or TransCon TLR7/8 Agonist in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies | ClinicalTrials.gov
  

Non-small cell

• Merck MK-7339-NCT04380636  Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012) - Full Text View - ClinicalTrials.gov
  

• Ascendis ASND0029: Study Details | A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or Chemotherapy or TransCon TLR7/8 Agonist in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies | ClinicalTrials.gov
  

Lung Cancer - Metastatic

Small cell

• Ascendis ASND0029 IL Believe: A Study of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov
  

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov
  

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

Non-small cell

• Ascendis ASND0029 IL Believe: A Study of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov

• BioAtla 3011-002 CAB-AXL-ADC Safety and Efficacy Study in Adults With NSCLC - Full Text View - ClinicalTrials.gov
  

• Miracogen MRG004A-001 A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• ImmuneOnco IMM2902, a HER2/SIRPα Bispecific mAb-Trap Antibody-receptor Fusion Protein, in Patients With HER2-expressing Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• RevMed  Evaluation of RMC-6236 in Subjects With Advanced Solid Tumors Harboring Specific Mutations in KRAS - Full Text View - ClinicalTrials.gov
  

• Duality Biologics DB1310-O-1001

• Janux: Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies - Full Text View - ClinicalTrials.gov

• Volastra Therapeutics VLS-1488-2201: Study Details | A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer | ClinicalTrials.gov

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov

• Ascendis TCTLR-101: Study Details | A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors | ClinicalTrials.gov

• Adanate ADA-011-001: Study Details | A Phase 1 Study of ADA-011 for Subjects With Advanced Solid Tumors | ClinicalTrials.gov

Colorectal cancer - Non-metastatic

• A021502-NCT02912559  Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair - Full Text View - ClinicalTrials.gov

• S0820-NCT01349881  S0820, Adenoma and Second Primary Prevention Trial - Full Text View - ClinicalTrials.gov
  

Colorectal cancer - Metastatic

• Miracogen MRG004A-001 A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Mirati Krystal-1 Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1 - Full Text View - ClinicalTrials.gov

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• ImmuneOnco  IMM2902, a HER2/SIRPα Bispecific mAb-Trap Antibody-receptor Fusion Protein, in Patients With HER2-expressing Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov

• Exelixis XL092-303 Study of XL092 + Atezolizumab vs Regorafenib in Subjects With Metastatic Colorectal Cancer - Full Text View - ClinicalTrials.gov

• RevMed  Evaluation of RMC-6236 in Subjects With Advanced Solid Tumors Harboring Specific Mutations in KRAS - Full Text View - ClinicalTrials.gov
  

• NuCana NuTide323: Study Details | A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer | ClinicalTrials.gov

• Janux: Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies - Full Text View - ClinicalTrials.gov

• Volastra Therapeutics VLS-1488-2201: Study Details | A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer | ClinicalTrials.gov

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov​

Blood cancer

• Cellectar CLOVER-1 Study of CLR 131 in Select B-Cell Malignancies (CLOVER-1) and Pivotal Expansion in Waldenstrom Macroglobulinemia - Full Text View - ClinicalTrials.gov

• Kymera KT333-TL-101 Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

Prostate cancer - Metastatic

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov
  

Melanoma and skin cancers - Non-Metastatic

• Ascendis ASND0029: Study Details | A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or Chemotherapy or TransCon TLR7/8 Agonist in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies | ClinicalTrials.gov
  

Melanoma and skin cancers - Metastatic

• Ascendis ASND0029 IL Believe: A Study of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov

• BioAtla 3021-001 CAB-ROR2-ADC Safety and Efficacy Study in Patients With TNBC or Head & Neck Cancer (Ph1) and NSCLC or Melanoma (Ph2) - Full Text View - ClinicalTrials.gov
  

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Adanate ADA-011-001: Study Details | A Phase 1 Study of ADA-011 for Subjects With Advanced Solid Tumors | ClinicalTrials.gov

• Ascendis TCTLR-101: Study Details | A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors | ClinicalTrials.gov​

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov

• Ascendis ASND0029: Study Details | A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or Chemotherapy or TransCon TLR7/8 Agonist in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies | ClinicalTrials.gov

Stomach and Esophagus cancer - Non-Metastatic

• No current trials available
  

Stomach and Esophagus cancer - Metastatic

• Miracogen MRG004A-001 A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• ImmuneOnco  IMM2902, a HER2/SIRPα Bispecific mAb-Trap Antibody-receptor Fusion Protein, in Patients With HER2-expressing Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• RevMed  Evaluation of RMC-6236 in Subjects With Advanced Solid Tumors Harboring Specific Mutations in KRAS - Full Text View - ClinicalTrials.gov
  

• Lisata LSTA1 Bolster: Study Details | A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors | ClinicalTrials.gov

• Ascendis TCTLR-101: Study Details | A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors | ClinicalTrials.gov​

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov

• Volastra Therapeutics VLS-1488-2201: Study Details | A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer | ClinicalTrials.gov

Bladder cancer - Non-Metastatic

• No current trials available
  

Bladder cancer - Metastatic

• Miracogen MRG004A-001 A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Volastra Therapeutics VLS-1488-2201: Study Details | A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer | ClinicalTrials.gov

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov

Kidney cancer - Non-Metastatic

• No current trials available
  

Kidney cancer - Metastatic

• Miracogen MRG004A-001 A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Janux: Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies - Full Text View - ClinicalTrials.gov

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov​

Liver and bile duct cancer - Non-Metastatic

• No current trials available
  

Liver and bile duct cancer - Metastatic

• Miracogen MRG004A-001 A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Lisata LSTA1 Bolster: Study Details | A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors | ClinicalTrials.gov

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov​

Brain cancer - Non-Metastatic

• No current trials available
  

Brain cancer - Metastatic

• No current trials available
  

Gynecologic malignancies - Non-Metastatic

• No current trials available
  

Gynecologic malignancies - Metastatic

• Ascendis ASND0029 IL Believe: A Study of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Miracogen MRG004A-001 A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors - Full Text View - ClinicalTrials.gov

• ZaiLab ZL-1211-001 A Study of ZL-1211 in Patients With Advanced Solid Tumor - Full Text View - ClinicalTrials.gov

• Zhuhai PRJ1-3024 A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
  

• ImmuneOnco  IMM2902, a HER2/SIRPα Bispecific mAb-Trap Antibody-receptor Fusion Protein, in Patients With HER2-expressing Advanced Solid Tumors - Full Text View - ClinicalTrials.gov

• RevMed  Evaluation of RMC-6236 in Subjects With Advanced Solid Tumors Harboring Specific Mutations in KRAS - Full Text View - ClinicalTrials.gov
  

• Kymera  Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors - Full Text View - ClinicalTrials.gov
  

• Ascendis ASND0029: Study Details | A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or Chemotherapy or TransCon TLR7/8 Agonist in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies | ClinicalTrials.gov

• Ascendis TCTLR-101: Study Details | A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors | ClinicalTrials.gov​

• BioAtla 3182-001: Study Details | Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma. | ClinicalTrials.gov

• Volastra Therapeutics VLS-1488-2201: Study Details | A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer | ClinicalTrials.gov

Supportive care

• LLD-001-NCT03972527  Photobiomodulation to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Head & Neck Cancer Patients - Full Text View - ClinicalTrials.gov
  

• Lutris L-02-01: Study Details | LUT014 for the Reduction of Dose-Limiting Acneiform Lesions Associated With EGFRI Treatment of mCRC | ClinicalTrials.gov
  

Biomarker Studies

• BeSpoke (Colorectal): BESPOKE Study of ctDNA Guided Therapy in Colorectal Cancer - Full Text View - ClinicalTrials.gov